Nikos K. Karamanos

Defined Extracellular Matrix Contexts Rewire 3D Breast Cancer Cell Models: Effects of Sulfated Hyaluronan in the Expression of Matrix Effector and Matrix-Based Cell Functional Properties

Background: Breast cancer progression is strongly influenced by tumor cell interactions with the extracellular matrix (ECM). Three-dimensional (3D) cell culture models provide more relevant systems for studying aspects of the tumor microenvironment (TME), including tumor architec...