Nicoletta Eliopoulos

Overcoming Intra-Articular Delivery Barriers in Cartilage Regeneration: Emerging Controlled-Release Strategies

Articular cartilage has a limited capacity for self-repair due to its avascular nature, dense extracellular matrix, and low cellularity. Current treatments for cartilage injury and osteoarthritis (OA) often provide temporary symptom relief but do not restore native tissue structu...

A SORT1-associated transcriptional signature links adipogenic plasticity, stemness and drug-resistance programs in 3D glioblastoma spheroids: dissection of ligand-dependent and ligand-independent arms

Three-dimensional (3D) culture of glioblastoma (GBM) cells recapitulates tumour-niche features lost in 2D monolayers, including stemness, metabolic plasticity and therapy resistance. By creating hydrophobic compartments that sequester lipophilic chemotherapeutics, increased adipo...