Nicoletta Basilico

Thiochromene Analogues as Antiparasitic Chemotype: Synthesis, Antiplasmodial and Antitrypanosomal Profiling, Experimental Validation, and Computational Insights into Trypanothione Reductase Inhibition

Abstract The emergence of drug resistance and the limited availability of effective therapeutics continue to hinder the treatment of protozoal diseases, highlighting the need for new chemotypes with broad-spectrum antiparasitic potential. In the present study, a series of nitro a...