Nicola Toschi

Localized brain delivery of drugs via focused ultrasound-responsive bi-layer nanobubbles

Focused ultrasound (FUS) in combination with micro- or nanobubbles is a promising strategy for transiently and non-invasively opening the blood-brain barrier (BBB) to enable targeted drug delivery to the brain. Here, we report a FUS-responsive delivery system using bi-layer nanob...

Multimodal radiomic and foundation-model MRI features converge on basal ganglia patterns in Parkinson’s motor subtypes

Parkinson’s disease (PD) comprises heterogeneous motor phenotypes, most prominently tremor-dominant (TD) and postural instability/gait difficulty (PIGD), which differ in progression, disability burden, and therapeutic response. Despite standardized Movement Disorder Society–Unifi...