Nicholas D. Klemen

Cell surface ADGRG1 and CD86 expression identifies antitumor CD4 + T cells in human cancer

Adoptive cell transfer of tumor infiltrating CD4 + T cells or T cells genetically modified to express antitumor CD4 + T cell receptors (TCRs) has shown clinical efficacy in patients with advanced solid tumors. We previously defined unique transcriptomic states of antitumor, neoan...