Niamh M. C. Connolly

Single-nucleus transcriptomic analysis reveals subfield-specific cell-to-cell synaptic reorganisation of the mouse hippocampus in focal temporal lobe epilepsy

Preclinical animal models are critical tools to study the pathophysiology of epilepsy. The intra-amygdala microinjection of kainic acid in mice recapitulates key features of drug-resistant temporal lobe epilepsy, including unilateral hippocampal pathology and broad resistance to...