Nesrine Rahmouni

Large-scale head-to-head comparison of on- and off-target profiles of [18F]Tauvid and [18F]MK6240 tau-PET in aging and Alzheimer’s disease

Abstract Background Tau-PET imaging enables in vivo quantification of neurofibrillary tangles, but tracers such as [ 18 F]Tauvid and [ 18 F]MK6240 present distinct affinities and off-target binding properties. Using the multicenter HEAD research cohort, a large-scale study design...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...