Nengquan Sheng

TRIP13 protects LDHA from FBXW7-mediated degradation and drives glycolytic plasticity in colorectal cancer

Abstract Background Metabolic plasticity enables colorectal cancer (CRC) cells to survive hypoxic and therapeutic stress. Lactate dehydrogenase A (LDHA) is a key regulator of glycolysis and lactate production, yet the mechanisms that maintain LDHA protein stability in CRC remain...