Neguin Ranjbar

Rare LRRFIP1 variants contribute to pathophysiology of severe early-onset scoliosis and common scoliotic phenotypes

Despite enormous advances in clinical genomics, idiopathic scoliosis remains an enigmatic condition with poorly understood genetic and pathophysiological underpinnings impeding molecular diagnosis and the development of targeted treatments. We performed linkage analysis, exome, g...

Regulation of mRNA poly(A) tail length governs mammalian body plan formation in gastruloids

Abstract The establishment of the body plan during gastrulation represents a hallmark of animal life. It emerges from the interplay of gene-regulatory programs and positional cues, yet how these signals are integrated post-transcriptionally remains largely unexplored. Here, we co...