Naveed A. Sattar

A metabolomic signature of weight-loss and its associations with BMI-linked diseases: A post-hoc analysis of two intervention trials and a mendelian randomisation study

Abstract Background Obesity is a major risk factor for heart failure (HF), but the molecular mediators linking adiposity to HF remain unclear. The molecular mechanisms by which weight loss reduces the risk of HF are also unknown. Understanding these mechanisms could highlight pot...

Subcutaneous adipocyte glucocorticoid-responsive transcripts after modest weight gain in South Asian and White European men: an exploratory longitudinal study

Abstract Aims/hypothesis Adipocyte glucocorticoid (GC)-responsive transcripts are linked to lipid storage and insulin sensitivity, and South Asians develop insulin resistance at lower BMI than White Europeans. We tested whether modest short-term weight gain was associated with ad...

Effects of Evolocumab on Mortality Outcomes in Patients Without Previous Myocardial Infarction or Stroke: A Prespecified Analysis of the VESALIUS-CV Randomized Clinical Trial

BACKGROUND: Evolocumab, a PCSK9 (proprotein convertase subtilisin–kexin type 9) inhibitor, significantly reduced the risk of cardiovascular events in patients without previous myocardial infarction or stroke in the VESALIUS-CV trial (Effect of Evolocumab in Patients at High Cardi...