Nathaniel K. Szymczak

Design Principles to Promote Acid–Base Interactions with a Weak Second-Sphere Lewis Acid

Abstract Boronic esters such as BPin are underutilized in secondary-sphere chemistry due to their weak acidity. We report a design strategy to enable cooperative binding with a BPin-appended NHC scaffold. Employing a shortened tether enhances preorganization and facilitates subst...