Nathalia Rocha de Oliveira

Therapeutic potential of haptoglobin in a murine model of sickle cell anemia

Chronic hemolytic anemia found in patients with sickle cell disease promotes an excess of free extracellular and intravascular hemoglobin, triggering a series of deleterious effects such as endothelial dysfunction, oxidative stress, and alterations in vascular tone, which lead to...