Nareshvarma Seelam

Structure-based discovery of phospholipase A1 (PlaF) inhibitors in Pseudomonas aeruginosa using integrated in silico and experimental approaches

Phospholipase A1 (PlaF) is a membrane-bound virulence factor in Pseudomonas aeruginosa, involved in glycerophospholipid remodeling and host-pathogen signaling. Inhibiting PlaF represents a promising strategy to reduce the virulence and pathogenesis of multidrug-resistant P. aerug...