Narayanan Krishnaswamy

Mutations in the SAF-A/B, acinus, and PIAS domain reduce the virulence of foot-and-mouth disease virus

Abstract Foot-and-mouth disease (FMD) is a transboundary viral disease affecting the animal trade. The leader proteinase (Lpro) of the FMD virus (FMDV) plays a critical role in virulence by suppressing the innate immune response of the host. We hypothesized that stable mutations...