Nancy J. Donovan

Network Localization of Anxiety as an Early Manifestation of Alzheimer's Disease-related Neurodegeneration

Objective Anxiety is a prominent neuropsychiatric symptom in preclinical Alzheimer's disease (AD), but the neural circuitry linking anxiety and AD remains uncharacterized. We assessed whether anxiety in preclinical AD is independently associated with AD-related neurodegeneration...

Longitudinal associations of hormone therapy and depressive symptoms in cognitively unimpaired older women

Abstract Background Women are disproportionately affected by depressive disorders relative to men, and mid-life differences like menopause can exacerbate symptoms. Hormone therapy (HT) is a common treatment to ease menopause transitions, including vasomotor and depressive symptom...