Nagarjun Narayanaswamy

DBCO/Azide-Appended Thioesters Enable Proximal-Dependent Cysteine to Lysine Labeling through S → N Acyl Shift

Abstract Thioester bonds are unique reactive functional groups with distinct reactivity profiles toward thiol and amine nucleophiles in aqueous solution. Here, we designed and synthesized thioester-appended clickable handles, including DBCO and azide tags, and investigated their...