Nabihah Tayob

A multivariate Bayesian biomarker screening algorithm that incorporates clinical covariates

Advanced hepatocellular carcinoma (HCC) has limited treatment options and poor survival. Early detection of HCC improves survival, but current ultrasound screening is inconsistent and poorly adhered to. Biomarker-based blood tests offer a more accurate, accessible, and reliable a...

Paxalisib with Trastuzumab for HER2-Positive Metastatic Breast Cancer with Active Brain Metastases: A Phase II Trial with Integrated Plasma and CSF ctDNA Analyses

Abstract Purpose: HER2+ breast cancer brain metastases (BCBM) frequently harbor PI3K/AKT/mTOR alterations. Preclinical HER2+ BCBM models demonstrated durable tumor regression with dual PI3K and mTOR inhibition. Our phase II trial evaluated paxalisib, a brain-penetrant dual PI3K/m...