Na Zhou

Single-cell atlas reveals ZBP1-driven inflammatory circuits in the nasal mucosa of allergic rhinitis

Allergic Rhinitis (AR) is driven by persistent mucosal inflammation and immune imbalance. The identification of susceptibility factors, particularly genes regulating mucosal immunity, contributes to the precision treatment of AR. We performed single-cell RNA sequencing (scRNA-seq...

LOX-1 promotes cardiac hypertrophy via p38MAPK signaling in alcoholic cardiomyopathy

Cardiac hypertrophy is a hallmark of alcoholic cardiomyopathy (ACM). The role of Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)/p38MAPK in mediating hypertrophy in ACM remains unclear. Primary neonatal rat ventricular cardiomyocytes (pNRVMs) were treated with eth...