N K Nanda

Intra-cluster receptor density (IRD): A molecular switch for TNFR1 clusters’ signaling

Abstract Tumor Necrosis Factor Receptor 1 (TNFR1) signaling regulates cell fate in inflammation, immune responses, and tumorigenesis. While TNF-α–mediated TNFR1 pathways are well known, the role of receptor clustering remains unclear. Utilizing homo-FRET using fluorescence anisot...