Myung-Ju Ahn

Molecular and immune heterogeneity across limited-stage and extensive-stage small cell lung cancer

Immune checkpoint inhibitors are now standard care for small-cell lung cancer (SCLC); however, a profound prognostic disparity persists between limited-stage (LS) and extensive-stage (ES) disease. Although clinical staging defines tumor spread, the specific molecular characterist...

Osimertinib–Savolitinib in Advanced NSCLC after Progression during EGFR-TKI Therapy

BackgroundSavolitinib is an oral, potent, highly selective MET–tyrosine kinase inhibitor (TKI). Combination therapy with savolitinib and osimertinib, an epidermal growth factor receptor (EGFR)–TKI, has shown activity in patients with EGFR-mutated, advanced non–small-cell lung can...

Tarlatamab–Durvalumab Maintenance for Extensive-Stage Small-Cell Lung Cancer

BackgroundPatients with extensive-stage small-cell lung cancer have poor outcomes, with a median overall survival of approximately 12 to 13 months. Tarlatamab (a bispecific T-cell engager targeting delta-like ligand 3 [DLL3] and CD3) was previously shown to improve survival as se...