Muthiah Vaduganathan

Gene Silencer Therapy in Transthyretin Amyloid Cardiomyopathy

Importance: Gene-silencing therapies reduce hepatic transthyretin (TTR) production and have been evaluated in phase 3 trials in TTR amyloid cardiomyopathy (ATTR-CM). However, differences in trial design and background therapies have limited assessment of the overall treatment eff...

Cardiovascular Risk Prediction with the Kidney Failure Risk Equation in the Chronic Renal Insufficiency Study

Background: The Kidney Failure Risk Equation (KFRE) is an established tool to predict the risk of kidney failure among patients with CKD. Patients with CKD more often die from cardiovascular (CV) causes than renal causes, and more often experience a non-fatal CV event than progre...