Muhammad Bilal

Age-associated transcriptomic heterogeneity in acute myeloid leukaemia: Evidence for mitochondrial metabolic rewiring and suppressed erythroid differentiation in older patients

Background: The incidence and clinical aggressiveness of acute myeloid leukaemia (AML) both increase with patient age, yet the transcriptional programmes that distinguish older from younger AML remain incompletely defined. We characterised age-associated gene expression patterns...

A Nonlinear Nonisothermal General Rate Model for Bimolecular Reactive Chromatography: A + B ⇌ C + D

Abstract Equilibrium-limited liquid-phase reactions can be intensified by coupling reaction and selective separation within a chromatographic bed, yet the interaction of reversible bimolecular kinetics with particle-scale mass and heat transport remains insufficiently resolved. F...

Analytical Solution and Temporal Moments of the Tempered Prabhakar Fractional General Rate Model for Linear Liquid Chromatography

Abstract Intraparticle transport in packed adsorption and chromatography columns is routinely represented by Fickian pore and surface diffusion, yet disordered pore networks and energetically heterogeneous surfaces frequently produce transport with long-lived memory that a single...