Moray J. Campbell

BUB1B Mitotic Kinase Dependency Reveals CENP-E Inhibition as a Tractable Approach for Castration and Enzalutamide Resistant Prostate Cancer

Abstract Castration-resistant prostate cancer (CRPC) progression despite treatment with potent androgen receptor (AR) antagonists such as enzalutamide is a major clinical challenge. The mitotic kinase BUB1B is a central member of an oncogenic seven-gene network that drives CRPC....

Breast cancer risk, epigenetic aging and DNA methylation clocks

Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death among women in the United States, and is globally a common and impactful cancer. Its distinct molecular subtypes, each defined by characteristic genomic and epigenomic profiles, var...

Single-nuclei RNA sequencing reveals obesity-associated rewiring of estrogen signaling in endometrioid adenocarcinoma

Endometrioid adenocarcinoma has one of the strongest body mass index associations of any solid tumor. This is widely attributed to amplification of estrogen-driven signaling via increased production of unopposed estrogen in peripheral adipose tissue. However, there is little evid...