Monika E. Hegi

BET inhibition induces coordinated repression of the stem cell-related HOX signature in GB uncovering an epigenetic vulnerability

Abstract Background Glioblastoma (GB) is the most aggressive primary brain tumor, characterized by therapy resistance, attributed to a multitude of epi-genetic changes resulting in phenotypic plasticity with altered cell states. To uncover druggable epigenetic vulnerabilities, we...