Mona Sadat Larijani

Context dependent roles of MicroRNA-377 in cancer from epigenetic silencing to therapeutic reactivation

MicroRNA-377 (miR-377) is a predominantly tumor-suppressive microRNA with context-dependent functions in cancer. Located within the imprinted DLK1-DIO3 region on chromosome 14q32, miR-377 regulates proliferation, apoptosis, invasion, metastasis, and treatment response, and its dy...