Mohammed Hakmi

Computational drug repurposing against histone acetyltransferase p300 for non-hormonal treatment of endometriosis using virtual screening and molecular dynamics simulations

Abstract Endometriosis is a gynecological disorder, characterized by debilitating pain and commonly associated with infertility. Medical therapies are often ineffective, with 25–34% of patients exhibit no or poor response, and many experiencing intolerable side effects that limit...

Integrative computational repositioning of Foretinib and PF-03715455 as potential GSTP1 inhibitors for cancer chemosensitization

Glutathione S-transferase P1 (GSTP1) plays a key role in tumor progression and drug detoxification, making it a promising target for reversing chemoresistance in cancer cells. Although several GSTP1 inhibitors have been identified, none have progressed to clinical use, mainly bec...