Mirko Manchia

Genome-wide analysis identifies pleiotropic genes shared between severe mental disorders and biomarkers of cellular aging

Severe mental disorders such as bipolar disorder (BD), major depressive disorder (MDD) and schizophrenia (SZ) are characterized by reduced life expectancy, premature mortality and alterations of aging biomarkers, leading to hypothesize that they might be associated with accelerat...

Knowledge, attitudes, and practices about severe mental illness and willingness-to-pay for a new integrated care model across 6 European countries: a study protocol

Background People with Severe Mental Illness (SMI) experience a 15–20-year shorter life expectancy than the general population, with increased premature deaths from somatic illnesses, and twice to more than four times the general population’s all-cause mortality risk. Integrated...

Emotional Reliance on Artificial Intelligence: A Scoping Review of AI Companionship and Mental Health Implications

Background: Artificial intelligence (AI)-driven conversational systems are increasingly capable of simulating empathy, adapting to individual users, and fostering emotional bonds that blur the boundary between tool and companion. This scoping review maps the extent and nature of...