Minxuan Huang

Saquinavir inhibits pyroptosis by regulating NLRP3 degradation to alleviate acute lung injury

Background In critically ill patients, sepsis can precipitate acute lung injury (ALI), a syndrome with high incidence in intensive care settings. Pyroptosis plays an important role in ALI, highlighting its potential as a drug target. The NLRP3-mediated classical pyroptosis pathwa...