Minoru Yoshida

A repurposed pseudoenzyme enables redox- and acetylation-dependent control of CoA transferase

CoA transferases play essential roles in short-chain fatty acid and acyl-CoA metabolism, yet how their activities are regulated in response to metabolic signals remains unclear. Here, we show that a CoA transferase from Thermus thermophilus is controlled by a two-layer mechanism...

Glutathione acts as an exometabolite that promotes growth recovery in fission yeast with defects in amino acid metabolism and cell polarity

ABSTRACT Microorganisms in nature form communities through diverse interactions, such as mutualism and competition, to adapt to their ecological environments. These interactions seem to be mediated by extracellular metabolites (exometabolites), yet the chemical and biological div...

Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress

Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce lethal oxidative stress and ferroptosis...