mingyu Li

Hydrogen gas alleviates osteoarthritis by inhibiting oxidative stress, apoptosis, inflammation, and extracellular matrix catabolism via the Nrf2/HO-1/NOX4 signaling pathway

Osteoarthritis (OA) is a chronic degenerative and debilitating disease. Reactive oxygen species (ROS) and oxidative stress play key roles in OA. NADPH oxidase 4 (NOX4) represents a major ROS source in chondrocytes. Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) activa...