Mingjie Mao

An engineered pneumolysin ΔA146 derivative induces apoptosis in breast cancer cells: an in vitro proof-of-concept for antibody-drug conjugate payload development

The therapeutic potential of antibody-drug conjugates (ADCs) is frequently undermined by the emergence of resistance to conventional payloads, which predominantly exert their effects through the disruption of intracellular targets such as microtubules or nuclear DNA. In pursuit o...