Mingji Dai

Convergent Total Synthesis of (−)-Methyl Gummiferolate Enabled by Pattern Recognition and Radical Cyclization

Abstract We report herein an enantioselective total synthesis of (−)-methyl gummiferolate, a complex diterpene natural product with a tetracyclic ent-atisane core including a bicyclo[2.2.2]octane subunit and three all-carbon quaternary centers. Gummiferolic acid has demonstrated...