Min Seo Kim

Fine-tuning of polygenic score to local data improves risk prediction and clinical implementation

Polygenic risk scores (PRS) hold promise for stratifying inherited disease risk, yet their clinical adoption remains constrained by poor transferability across populations and cohorts. To bridge this gap, we propose a pragmatic framework that recalibrates externally derived PRSs...

Global, regional, and national burden of motor neuron diseases, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Purpose: Healthcare planning and resource allocation require accurate estimates of the burden of motor neuron diseases (MNDs). This study evaluated the global impact of MNDs from 1990 to 2021 as part of the Global Burden of Disease (GBD) Study 2021. Methods: GBD 2021 data were us...