Min Guo

PAX3 deficiency is associated with NLRP3-related inflammatory signaling and hearing loss in a mouse model of Waardenburg syndrome

Abstract PAX3 gene defects are a major cause of Waardenburg syndrome (WS), a genetic disorder characterized by pigmentation abnormalities and sensorineural hearing loss. However, the molecular mechanisms by which PAX3 deficiency contributes to hearing impairment remain incomplete...