Mikołaj Stańczak

The Tenocyte from Atom to Cell: A Critical Multiscale Synthesis Linking Collagen Chemistry, Tissue Mechanics, Cell Mechanobiology and Mathematical Modelling

The tenocyte builds, maintains, senses and degrades one of the most mechanically demanding extracellular matrices in vertebrates, yet the chemical, physical, biological and mathematical descriptions of this system have developed in largely separate literatures. This review examin...

Drugging the Undruggable in Oncology: Structural Computation, Machine Learning, and Generative AI for Historically Intractable Targets

For four decades the central oncogenic drivers of human cancer the RAS GTPases, the transcription-factor MYC, mutant p53, and the protein-tyrosine phosphatases, fusion oncoproteins and intrinsically disordered regulators that surround them were regarded as undruggable: lacking de...