Mikkel Heide Schierup

Arrest of human spermatogenesis at the pachytene stage is frequently accompanied by disruption of the piRNA pathway

Abstract Recent genetic studies have identified defects in the PIWI-interacting RNA (piRNA) pathway to cause nonobstructive azoospermia. However, limited knowledge of piRNA function in human spermatogenesis makes it difficult to quantify the number of cases affected. Central to t...