Mihnea Zdrenghea

The Epigenetic Architecture of Classical Hodgkin Lymphoma: Lineage Erasure, Immune Escape, and Therapeutic Reprogramming

Classical Hodgkin lymphoma (cHL) is distinguished by a rare population of Hodgkin and Reed–Sternberg (HRS) cells that has largely extinguished its germinal center (GC) B-cell identity while maintaining survival, immune escape, and dependence on a highly organized tumor microenvir...