Miguel Gomez Fontela

CAR signaling instructs divergent metabolic reprogramming and functional fates in αβ and γδ T cells

γδ T-cell-based immunotherapies have become relevant as alternatives to conventional αβ T-cell products, with preclinical data demonstrating tumor burden reduction and the mitigation of tumor-induced tissue damage. Given that most CAR constructs have been optimized for αβ T cells...