Michael X. Zhu

DHHC21 is a STIM1 protein S-acyltransferase that modulates immune function in vivo

Depletion of calcium from ER stores leads to the activation of calcium channels on the plasma membrane known as store-operated calcium entry. The proteins STIM1 and STIM2 function as ER calcium sensors, and upon store depletion, they undergo a conformational change that allows th...

Orally available Colivin traps TRPV3 in an inactive state and suppresses intestinal inflammation

Abstract Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel highly expressed in the skin and intestine. While its roles in itch and skin inflammation are established, the physiological role of TRPV3 in the intestine remains relatively poorly unders...