Michael V. Airola

Developmentof a FRET-Based Assay for Human NeutralSphingomyelinase 2

Abstract Neutral sphingomyelinase 2 (nSMase2) is a membrane-bound enzyme that hydrolyzes sphingomyelin (SM) into ceramide and phosphocholine. By generating the bioactive lipid ceramide, nSMase2 plays a critical role in cell stress responses and in regulating exosomes that package...