Michael S. Rafii

Cerebral microhemorrhage and cognition in preclinical Alzheimer’s disease

BACKGROUND: Clarifying whether incident cerebral microhemorrhages (CMHs) contribute to early cognitive or functional decline is increasingly important in the context of anti-amyloid therapies. OBJECTIVE: To determine whether incident CMHs are associated with longitudinal changes...

Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder

Abstract Background Down syndrome regression disorder (DSRD) causes a rapid loss of cognitive, behavioral, and daily living skills, usually in adolescents and young adults with Down syndrome. Because people with Down syndrome have a high lifetime risk of Alzheimer’s disease, we e...

Sex-specific biological aging clocks across organs and omics

Sex differentially shapes aging, neurodevelopment and neurodegenerative diseases such as Alzheimer’s disease (AD). However, most biological aging clocks (artificial intelligence-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex in...