Michael N. Grzybowski

Disruption of local CTCF binding impairs renin expression and blood pressure response in Dahl salt-sensitive rats

Most genetic variants associated with any complex trait are found in non-coding regions. Multiple studies have reported enrichment in single nucleotide polymorphisms (SNPs) found in specific sequences bound by CCCTCF-binding factor (CTCF). CTCF binds DNA to establish boundaries,...