Michael Lowe

PolarTIL programming reveals an essential role for TGF-β1 in antitumor memory in human cutaneous malignancies

Abstract Tumor-infiltrating lymphocyte (TIL) therapy can induce tumor regression in solid malignancies, yet durable responses remain limited, highlighting the need for more effective cell products. Here, we generated a novel TIL product, PolarTIL, by polarizing murine and human T...