Michael Linnebacher

Limits of Predicting Colorectal Cancer PDX Engraftment: A Specimen-Grouped Machine Learning Analysis of 1007 Establishment Attempts

Background: Patient-derived xenograft (PDX) models retain clinically relevant features of the donor tumor, but the establishment of colorectal cancer (CRC) PDX models succeeds in only a fraction of attempts. Whether routinely available clinicopathological and experimental variabl...