Michael Hecht-Bucher

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF ‐Tu for AMPylation

Fic enzymes mediate diverse post-translational modifications, including adenosine monophosphate (AMP) transfer and removal, referred to as AMPylation and deAMPylation, respectively. We identified the prokaryotic translation elongation factor Tu (EF-Tu) as an AMPylation target of...