Michaël Grynberg

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

Estradiol (E2) regulates ovarian follicular development and granulosa cell (GC) function primarily through estrogen receptor β (ERβ). Human GCs express several ERβ isoforms, including ERβ1, ERβ2, ERβ4, and ERβ5, but how their relative abundance modulates estrogen signaling remain...

Mild stimulated cycles with timed intercourse in women with idiopathic infertility and decreased ovarian reserve: can it be a therapeutic option before oocyte donation?

Woman natural fertility declines physiologically with age, driven by accelerated follicular depletion and subtle ovulatory dysfunctions. As age at first pregnancy increases, women with decreased ovarian reserve (DOR) represent a growing proportion of those seeking assisted reprod...