Michael A. Riehle

Limitation of pantothenate bioavailability in Anopheles stephensi by second-generation pantazines enhances restriction of Plasmodium development

Plasmodium parasites require pantothenate (Pan) from their hosts to synthesize coenzyme A (CoA), an essential metabolic cofactor. While blood-stage parasites can utilize both Pan and the immediate CoA precursor phosphopantetheine from mammals to synthesize CoA, mosquito-stage par...