Michael A. Curran

RhoA Y42C drives cell plasticity and PD-1-mediated immune evasion of diffuse gastric cancer

Diffuse gastric cancer (DGC) is an aggressive gastric cancer subtype with a poor prognosis. The RHOA Y42C mutation is recurrent in DGC, but its independent oncogenic role is unclear. Next-Generation Sequencing of 431 DGC cases revealed that most RHOA mutations occurred without CD...