Miaomiao Pan

A small molecule increases mycobacterial translation fidelity without a fitness cost by targeting ribosomal protein S5

A central dogma of molecular biology is the "speed-accuracy trade-off," where ribosomes must slow down to ensure accurate protein synthesis. In mycobacteria, a high basal level of mistranslation at glutamine and asparagine codons, caused by an indirect tRNA aminoacylation pathway...