Mian Zhang

Oxygen-vacancy-rich LDH sonosensitizers potentiate narrow-spectrum antibiotics via membrane-disruption strategy for mixed bacterial wound infections

Mixed bacterial infections, including Gram-positive and Gram-negative pathogens, remain a major global health concern. Achieving efficient treatment of synergistic polymicrobial infections stills a tremendous clinical challenge due to antibiotic permeability barriers and resistan...

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Pathological cartilage calcification represents a pivotal pathological alteration in osteoarthritis (OA), yet its underlying mechanisms remain poorly understood. Exosomes are involved in facilitating calcification, and their biogenesis may be linked to autophagy disruption. Howev...